CF by the Numbers

Cystic fibrosis is a rare, life-shortening genetic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator – or CFTR – gene. There are around 2000 identified mutations in the gene, 127 of which are currently known to cause CF. Since the discovery of the CFTR gene in 1989, doctors and scientists have learned a lot more about the cause of CF and how the disease affects the body.

Genetics And CF

127 CFTR mutations are known to cause CF

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Genetics And CF

CF: Facts and Figures

75,000 people in North America, Europe and Australia have CF

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CF: Facts and Figures

The Biology of CF

CF affects the body in many ways

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The Biology of CF
Learn More About CF

You can learn more about the genetics of CF and symptoms of the disease by watching the short videos below and by visiting cfsource.com. CF Source is an educational web site developed by Vertex.

CFTR Proteins

How CFTR Proteins Are Made and What Happens When They Don't Work Right

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CFTR Proteins

CFTR Protein Defects:
Function

How Certain CFTR Mutations Affect the Way CFTR Proteins Function

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CFTR Protein Defects:<br />Function

CFTR Protein Defects:
Quantity

How Certain CFTR Mutations Affect the Quantity of CFTR Proteins at the Cell Surface

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CFTR Protein Defects:<br />Quantity

Symptoms: Lungs

What Happens in the Lungs of a Person With CF

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Symptoms: Lungs

Symptoms:
Digestive System

What Happens in the Digestive System of a Person With CF

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Symptoms:<br />Digestive System
CF Resources

Many additional resources are available to help you learn more about CF and CF research. Here are just a few:

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